2026-06-14T03:31:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/77572024-09-27T09:05:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fuentes Q, Eduardo
author
Fuentes Q, Francisco
author
Andres, Vicente
author
Pello, Oscar M
author
Font de Mora, Jaime
author
Palomo G, Iván
funder
Centro de Estudios en Alimentos Procesados (Chile)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
2019-06-07T12:54:07Z
2019-06-07T12:54:07Z
2013
Platelets. 2013; 24(4):255-62
10.3109/09537104.2012.690113
1369-1635
0953-7104
Platelets
22671308
http://hdl.handle.net/20.500.12105/7757
Platelets, crucial mediators of the acute complications of atherosclerosis that cause life-threatening ischemic events at late stages of the disease, are also key effectors of inflammation throughout plaque development through their interaction with endothelial and immune cells in the injured vessel wall. During the first steps of atherosclerosis, blood inflammatory leukocytes interact with the damaged endothelium in areas rich in platelet aggregates. In late stages of the disease, platelets secrete several inflammatory molecules, even without forming aggregates. These molecules exacerbate the inflammation and induce the transition from chronic to acute disease, featuring increased instability of the atherosclerotic lesion that results in plaque rupture and thrombosis. Moreover, platelets play an important role in vascular wall remodeling induced by chronic inflammation by controlling vascular cell differentiation and proliferation. In this review, we discuss the role of platelets as cell mediators that link inflammation and thrombosis in atherosclerotic disease and their potential in the development of new therapeutic tools to fight cardiovascular disease.
eng
Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis
journal article
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URL
https://repisalud.isciii.es/bitstreams/f00ab0c8-fe2e-415b-bf50-364b62d333d6/download
File
MD5
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application/pdf
RoleOfPlateletsAsMediators_2013.pdf
URL
https://repisalud.isciii.es/bitstreams/1de54ff0-0f6e-4868-a644-ea1e534e42b9/download
File
MD5
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text/plain
RoleOfPlateletsAsMediators_2013.pdf.txt