2026-06-14T10:38:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/77222024-09-27T08:11:28Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cordani, Marco
author
Sanchez-Alvarez, Miguel
author
Strippoli, Raffaele
author
Bazhin, Alexandr V
author
Donadelli, Massimo
funder
Comunidad de Madrid (España)
2019-06-04T10:55:33Z
2019-06-04T10:55:33Z
2019
Oxidative Med Cell Longev. 2019:1283075
10.1155/2019/1283075
1942-0900
Oxidative Medicine and Cellular Longevity
http://hdl.handle.net/20.500.12105/7722
Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their integration and their contribution to cell homeostasis and disease is still limited. Sestrins (SESNs) belong to a family of highly conserved stress-inducible proteins that orchestrate antioxidant and autophagy-regulating functions protecting cells from various noxious stimuli, including DNA damage, oxidative stress, hypoxia, and metabolic stress. They are also relevant modulators of metabolism as positive regulators of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibitors of mammalian target of rapamycin complex 1 (mTORC1). Since perturbations in these pathways are central to multiple disorders, SESNs might constitute potential novel therapeutic targets of broad interest. In this review, we discuss the current understanding of regulatory and effector networks of SESNs, highlighting their significance as potential biomarkers and therapeutic targets for different diseases, such as aging-related diseases, metabolic disorders, neurodegenerative diseases, and cancer.
eng
Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
journal article
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URL
https://repisalud.isciii.es/bitstreams/5aa1fd18-b68c-4794-b83c-c20f9eb9a75e/download
File
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application/pdf
SestrinsAtTheInterface_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/cf491d43-4f77-41e1-9ed4-b662c55e778f/download
File
MD5
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text/plain
SestrinsAtTheInterface_2019.pdf.txt