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oai:repisalud.isciii.es:20.500.12105/77222024-09-27T08:11:28Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Cordani, Marco author Sanchez-Alvarez, Miguel author Strippoli, Raffaele author Bazhin, Alexandr V author Donadelli, Massimo author 2019 Reactive oxygen species (ROS) and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their integration and their contribution to cell homeostasis and disease is still limited. Sestrins (SESNs) belong to a family of highly conserved stress-inducible proteins that orchestrate antioxidant and autophagy-regulating functions protecting cells from various noxious stimuli, including DNA damage, oxidative stress, hypoxia, and metabolic stress. They are also relevant modulators of metabolism as positive regulators of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibitors of mammalian target of rapamycin complex 1 (mTORC1). Since perturbations in these pathways are central to multiple disorders, SESNs might constitute potential novel therapeutic targets of broad interest. In this review, we discuss the current understanding of regulatory and effector networks of SESNs, highlighting their significance as potential biomarkers and therapeutic targets for different diseases, such as aging-related diseases, metabolic disorders, neurodegenerative diseases, and cancer. Oxidative Med Cell Longev. 2019:1283075 10.1155/2019/1283075 1942-0900 Oxidative Medicine and Cellular Longevity http://hdl.handle.net/20.500.12105/7722 Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease