2026-04-29T04:08:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/77172024-11-28T16:10:52Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938
Repisalud
author
Ochando, Jordi
author
Conde-San Román, Patricia
author
Utrero-Rico, Alberto
author
Paz-Artal, Estela
funder
Unión Europea. European Cooperation in Science and Technology (COST)
funder
Comunidad de Madrid (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Asociación Española Contra el Cáncer
2019-06-04T08:43:45Z
2019-06-04T08:43:45Z
2019
Front Immunol. 2019 Mar 6;10:374.
1664-3224
http://hdl.handle.net/20.500.12105/7717
30894860
10.3389/fimmu.2019.00374
1664-3224
Frontiers in immunology
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strategies that regulate the induction and development of MDSC have been the center of scientist attention. Here we review literature regarding induction of MDSC with demonstrated suppressive function among different types of allografts and their mechanism of action. While manipulation of MDSC represents a potential therapeutic approach for the promotion of donor specific tolerance in solid organ transplantation, further characterization of their specific phenotype, which distinguishes MDSC from non-suppressive myeloid cells, and detailed evaluation of the inhibitory mechanism that determines their suppressive function, is necessary for the realistic application of MDSC as biomarkers in health and disease and their potential use as immune cell therapy in organ transplantation.
eng
MDSC
Immune tolerance
Immunophenotyping
Myeloid cells
Transplantation
Tolerogenic Role of Myeloid Suppressor Cells in Organ Transplantation
journal article
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URL
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File
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application/pdf
TolerogenicRoleOfMyeloid_2019.pdf
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TolerogenicRoleOfMyeloid_2019.pdf.txt