2026-04-29T04:08:51Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/77172024-11-28T16:10:52Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938

00925njm 22002777a 4500 dc Ochando, Jordi author Conde-San Román, Patricia author Utrero-Rico, Alberto author Paz-Artal, Estela author 2019 Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strategies that regulate the induction and development of MDSC have been the center of scientist attention. Here we review literature regarding induction of MDSC with demonstrated suppressive function among different types of allografts and their mechanism of action. While manipulation of MDSC represents a potential therapeutic approach for the promotion of donor specific tolerance in solid organ transplantation, further characterization of their specific phenotype, which distinguishes MDSC from non-suppressive myeloid cells, and detailed evaluation of the inhibitory mechanism that determines their suppressive function, is necessary for the realistic application of MDSC as biomarkers in health and disease and their potential use as immune cell therapy in organ transplantation. Front Immunol. 2019 Mar 6;10:374. 1664-3224 http://hdl.handle.net/20.500.12105/7717 30894860 10.3389/fimmu.2019.00374 1664-3224 Frontiers in immunology MDSC Immune tolerance Immunophenotyping Myeloid cells Transplantation Tolerogenic Role of Myeloid Suppressor Cells in Organ Transplantation