2026-07-21T16:28:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/77022024-09-27T20:42:57Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Mellado, Emilia
author
Garcia-Effron, Guillermo
author
Buitrago, Maria Jose
author
Alcazar-Fuoli, Laura
author
Cuenca-Estrella, Manuel
author
Rodriguez-Tudela, Juan Luis
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia y Tecnología (España)
2019-05-31T10:32:26Z
2019-05-31T10:32:26Z
2005-06
Antimicrob Agents Chemother. 2005;49(6):2536-8.
10.1128/AAC.49.6.2536-2538
0066-4804
Antimicrobial agents and chemotherapy
15917566
http://hdl.handle.net/20.500.12105/7702
The role of Aspergillus fumigatus 14alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were morphologically indistinguishable from the wild-type strain, retaining the ability to cause pulmonary disease in neutropenic mice.
eng
Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility
journal article
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