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oai:repisalud.isciii.es:20.500.12105/77022024-09-27T20:42:57Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Mellado, Emilia author Garcia-Effron, Guillermo author Buitrago, Maria Jose author Alcazar-Fuoli, Laura author Cuenca-Estrella, Manuel author Rodriguez-Tudela, Juan Luis author 2005-06 The role of Aspergillus fumigatus 14alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were morphologically indistinguishable from the wild-type strain, retaining the ability to cause pulmonary disease in neutropenic mice. Antimicrob Agents Chemother. 2005;49(6):2536-8. 10.1128/AAC.49.6.2536-2538 0066-4804 Antimicrobial agents and chemotherapy 15917566 http://hdl.handle.net/20.500.12105/7702 Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility