2026-08-29T18:28:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76972024-10-07T10:52:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Pedro-Cuesta, Jesus de
author
Mahillo-Fernandez, Ignacio
author
Rábano, Alberto
author
Calero, Miguel
author
Cruz, Mabel
author
Siden, Ake
author
Laursen, Henning
author
Falkenhorst, Gerhard
author
Mølbak, Kåre
funder
Fundación Centro De Investigación De Enfermedades Neurológicas
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
funder
Unión Europea. Comisión Europea
2019-05-30T09:47:31Z
2019-05-30T09:47:31Z
2011-02
J Neurol Neurosurg Psychiatry. 2011; 82(2):204-12
10.1136/jnnp.2009.188425
1468-330X
Journal of neurology, neurosurgery, and psychiatry
20547628
http://hdl.handle.net/20.500.12105/7697
OBJECTIVES: Evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains debatable in part due to misclassification of exposure levels. In a registry-based case-control study, the authors applied a risk-based classification of surgical interventions to determine the association between a history of surgery and sCJD. DESIGN: Case-control study, allowing for detailed analysis according to time since exposure. SETTING: National populations of Denmark and Sweden. PARTICIPANTS: From national registries of Denmark and Sweden, the authors included 167 definite and probable sCJD cases with onset during the period 1987-2003, 835 age-, sex- and residence-matched controls and 2224 unmatched. Surgical procedures were categorised by anatomical structure and presumed risk of transmission level. The authors used logistic regression to determine the odds ratio (OR) for sCJD by surgical interventions in specified time-windows before disease-onset. RESULTS: From comparisons with matched controls, procedures involving retina and optic nerve were associated with an increased risk at a latency of ≥1 year OR (95% CI) 5.53 (1.08 to 28.0). At latencies of 10 to 19 years, interventions on peripheral nerves 4.41 (1.17 to 16.6) and skeletal muscle 1.58 (1.01 to 2.48) were directly associated. Interventions on blood vessels 4.54 (1.01 to 20.0), peritoneum 2.38 (1.14 to 4.96) and skeletal muscle 2.04 (1.06 to 3.92), interventions conducted by vaginal approach 2.26 (1.14 to 4.47) and a pooled category of lower-risk procedures 2.81 (1.62 to 4.88) had an increased risk after ≥20 years. Similar results were found when comparing with unmatched controls. INTERPRETATION: This observation is in concordance with animal models of prion neuroinvasion and is likely to represent a causal relation of surgery with a non-negligible proportion of sCJD cases.
eng
Nosocomial transmission of sporadic Creutzfeldt-Jakob disease: results from a risk-based assessment of surgical interventions
journal article
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NosocomialTransmissionSporadicCreutzfeldt_2010.pdf
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NosocomialTransmissionSporadicCreutzfeldt_2010.pdf.txt