2026-07-21T16:13:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76922024-09-27T10:06:36Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_19604col_20.500.12105_19609col_20.500.12105_19607
Repisalud
author
Lopez-Huertas, Maria Rosa
author
Callejas, Sergio
author
Abia, David
author
Dopazo, Ana
author
AlcamÃ, José
author
Coiras, Mayte
2019-05-29T08:57:43Z
2019-05-29T08:57:43Z
2009
Nucleic Acids Res. 2010 Jun;38(10):3287-307.
10.1186/1742-4690-6-S2-P1
1742-4690
Retrovirology
http://hdl.handle.net/20.500.12105/7692
The human immunodeficiency virus type 1 (HIV-1) encodes the 110 amino acid-pleiotropic nuclear transcriptional activator Tat that is not only essential for efficient elongation of viral transcripts, but also regulates both cellular protein and gene expression. Tat encoding gene consists of two spliced exons separated in the HIV-1 genome by more than 2.300 nucleotides. First 72 residues at the N-terminal encoded by the first exon appear to be sufficient for transcriptional activity, but the integrity of the coding second exon in most lentiviral genomes suggests that it should have some biological importance. In this work, we demonstrate that the second exon completes Tat function.
eng
Human Immunodeficiency Virus
Jurkat Cell
Binding Strength
Cellular Movement
Modifications in host cell structure and functions mediated by Tat intracellular expression are greatly dependent on the second exon
conference poster
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URL
https://repisalud.isciii.es/bitstreams/1d78c900-5262-4043-9a25-4acd4bf5b928/download
File
MD5
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application/pdf
ModificationsInHostCell_2009.pdf
URL
https://repisalud.isciii.es/bitstreams/1a95f527-f1ab-4000-8158-6e1ffe5fa770/download
File
MD5
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text/plain
ModificationsInHostCell_2009.pdf.txt