2026-06-14T13:00:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76912024-10-07T10:52:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Esteban-Vasallo, María D
author
Aragones, Nuria
author
Pollan-Santamaria, Marina
author
Lopez-Abente, Gonzalo
author
Perez-Gomez, Beatriz
2019-05-29T08:51:00Z
2019-05-29T08:51:00Z
2012-10
Environ Health Perspect. 2012; 120(10): 1369–1377.
10.1289/ehp.1204952
1552-9924
Environmental health perspectives
22591711
http://hdl.handle.net/20.500.12105/7691
BACKGROUND: Placental tissue may furnish information on the exposure of both mother and fetus. Mercury (Hg), cadmium (Cd), and lead (Pb) are toxicants of interest in pregnancy because they are associated with alterations in child development. OBJECTIVES: The aim of this study was to summarize the available information regarding total Hg, Cd, and Pb levels in human placenta and possible related factors. METHODS: We performed a systematic search of PubMed/MEDLINE, EMBASE, Lilacs, OSH, and Web of Science for original papers on total Hg, Cd, or Pb levels in human placenta that were published in English or Spanish (1976-2011). Data on study design, population characteristics, collection and analysis of placenta specimens, and main results were extracted using a standardized form. RESULTS: We found a total of 79 papers (73 different studies). Hg, Cd, and Pb levels were reported in 24, 46, and 46 studies, respectively. Most studies included small convenience samples of healthy pregnant women. Studies were heterogeneous regarding populations selected, processing of specimens, and presentation of results. Hg concentrations > 50 ng/g were found in China (Shanghai), Japan, and the Faroe Islands. Cd levels ranged from 1.2 ng/g to 53 ng/g and were highest in the United States, Japan, and Eastern Europe. Pb showed the greatest variability, with levels ranging from 1.18 ng/g in China (Shanghai) to 500 ng/g in a polluted area of Poland. CONCLUSION: The use of the placenta as a biomarker to assess heavy metals exposure is not properly developed because of heterogeneity among the studies. International standardized protocols are needed to enhance comparability and increase the usefulness of this promising tissue in biomonitoring studies.
eng
Biomonitoring
Cadmium
Lead
Mercury
Metals
Placenta
Mercury, cadmium, and lead levels in human placenta: a systematic review
journal article
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MercuryCadmiumAndLead_2012.pdf
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MercuryCadmiumAndLead_2012.pdf.txt