2026-04-29T06:15:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76862025-04-29T13:38:55Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16958col_20.500.12105_16971col_20.500.12105_16977
Repisalud
author
Medrano, Luz Maria
author
Gutiirrez-Rivas, Monica
author
Blanco, Julià
author
García, Marcial
author
Jimenez-Sousa, Maria Angeles
author
Pacheco, Yolanda María
author
Montero, Marta
author
Iribarren, José Antonio
author
Bernal, Enrique
author
Martínez, Onofre Juan
author
Benito, José Miguel
author
Rallón, Norma
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
2019-05-28T09:45:24Z
2019-05-28T09:45:24Z
2018
J Transl Med. 2018 Dec 6;16(1):343.
1479-5876
http://hdl.handle.net/20.500.12105/7686
30522500
10.1186/s12967-018-1717-y
1479-5876
Journal of translational medicine
BACKGROUND: The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. METHODS: This is a retrospective study of 324 naïve cART patients with CD4+ < 200 cells/mm3, who were followed-up during 24 months after initiating cART. All patients had undetectable HIV viral load during the follow-up. Besides, we included 141 healthy controls. MtDNA genotyping was performed by using Sequenom's MassARRAY platform. The primary outcome variable was the slope of CD4+ recovery. Patients were stratified into two groups by the median slope value of CD4+ (9.65 CD4+ cells/mm3/month). Logistic regression analyses were performed to calculate the odds of CD4+ recovery according to mtDNA haplogroups. RESULTS: Our study included European HIV-infected patients within the N macro-cluster. The baseline values of CD4+ T-cells were similar between groups of patients stratified by the P50th of the slope of CD4+ T-cells recovery. Patients in the low CD4+ T-cells recovery group were older (p = 0.001), but this variable was included in the multivariate models. When we analyzed the frequencies of mtDNA haplogroups, no significant differences between HIV-infected individuals and healthy controls were found. We did not find any significant association between mtDNA haplogroups and the slope of CD4+ T-cells recovery by linear regression analysis. However, Patients carrying haplogroup H had a higher odds of having a better CD4+ recovery (> 9.65 CD4+ cells/mm3/month) than patients without haplogroup H (p = 0.032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9.65 CD4+ cells/mm3/month [adjusted odds ratio (aOR) = 1.75 (95% CI = 1.04; 2.95); p = 0.035]. CONCLUSIONS: European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV-infected patients starting cART with CD4+ < 200 cells/mm3.
eng
HIV
Haplogroups
Immune reconstitution
Mitochondria
cART
mtDNA
Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
research article
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MitochondrialHaplogroupHIs_2018.pdf
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MitochondrialHaplogroupHIs_2018.pdf.txt