2026-06-14T05:06:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76612024-09-27T09:28:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fuster, Jose J.
author
Castillo, Ana I
author
Zaragoza, Carlos
author
Ibáñez, Borja
author
Andres, Vicente
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
2019-05-23T09:29:23Z
2019-05-23T09:29:23Z
2012
Prog Mol Biol Transl Sci. 2012; 105:1-23
10.1016/B978-0-12-394596-9.00001-9
1878-0814
18771173
Progress in molecular biology and translational science
22137427
http://hdl.handle.net/20.500.12105/7661
Cardiovascular disease is currently the predominant cause of mortality worldwide and its incidence is expected to increase significantly during the next decades owing to the unhealthy effects of modern lifestyle habits (e.g., obesity and lack of physical exercise). Cardiovascular death is frequently associated with acute myocardial infarction or stroke, which are generally the ultimate consequence of an underlying atherosclerotic process. Small and big animal models are valuable tools to understand the molecular mechanisms underlying atherosclerotic plaque formation and progression, as well as the occurrence of associated ischemic events. Moreover, animal models of atherosclerosis are pivotal for testing mechanistic hypothesis and for translational research, including the assessment of dietary and/or pharmacological interventions and the development of imaging technologies and interventional devices. In this chapter, we will describe the most widely used animal models that have permitted major advances in atherosclerosis research and significant improvements in the treatment and diagnosis of atherosclerotic disease.
eng
Animal models of atherosclerosis
journal article
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URL
https://repisalud.isciii.es/bitstreams/24975022-2a6c-4b59-a0f5-eb7fe7ca2dee/download
File
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application/pdf
AnimalModelsAtherosclerosis_2011.pdf
URL
https://repisalud.isciii.es/bitstreams/acf76b7c-b695-4480-8b56-2bb41f9d6f5b/download
File
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AnimalModelsAtherosclerosis_2011.pdf.txt