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00925njm 22002777a 4500 dc Fuster, Jose J. author Castillo, Ana I author Zaragoza, Carlos author Ibáñez, Borja author Andres, Vicente author 2012 Cardiovascular disease is currently the predominant cause of mortality worldwide and its incidence is expected to increase significantly during the next decades owing to the unhealthy effects of modern lifestyle habits (e.g., obesity and lack of physical exercise). Cardiovascular death is frequently associated with acute myocardial infarction or stroke, which are generally the ultimate consequence of an underlying atherosclerotic process. Small and big animal models are valuable tools to understand the molecular mechanisms underlying atherosclerotic plaque formation and progression, as well as the occurrence of associated ischemic events. Moreover, animal models of atherosclerosis are pivotal for testing mechanistic hypothesis and for translational research, including the assessment of dietary and/or pharmacological interventions and the development of imaging technologies and interventional devices. In this chapter, we will describe the most widely used animal models that have permitted major advances in atherosclerosis research and significant improvements in the treatment and diagnosis of atherosclerotic disease. Prog Mol Biol Transl Sci. 2012; 105:1-23 10.1016/B978-0-12-394596-9.00001-9 1878-0814 18771173 Progress in molecular biology and translational science 22137427 http://hdl.handle.net/20.500.12105/7661 Animal models of atherosclerosis