2026-08-29T09:56:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76602024-09-27T09:09:40Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Jiménez-Navarro, Manuel F
author
Bueno, Hector
author
Álvarez-Sala, Luis
author
Rodríguez-Losada, Noela
author
Andres, Vicente
author
González-Navarro, Herminia
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
2019-05-23T09:10:56Z
2019-05-23T09:10:56Z
2011
ISRN Cardiol. 2011; 2011:740585
10.5402/2011/740585
2090-5599
2090-5580
ISRN cardiology
22347652
http://hdl.handle.net/20.500.12105/7660
The mechanisms underlying the increased risk of cardiovascular disease associated with diabetes mellitus (DM) are not fully defined. Insulin resistance in human metabolic syndrome patients is associated with decreased expression of the insulin receptor substrate-2- (Irs2-) AKT2 axis in mononuclear leukocytes (MLs). Moreover, acute coronary syndrome (ACS) has been linked through genome-wide association studies to the 2q36-q37.3 locus, which contains the Irs1 gene. Here, we investigated the expression of insulin-signaling pathway genes in MLs from patients with DM, ACS, and ACS plus DM. Quantitative real-time PCR expression studies showed no differences in the mRNA levels of Irs2, Akt2, and Akt1 among all patients. However, Irs1 mRNA expression was significantly increased in patients with ACS-diabetics and nondiabetics-compared with diabetic patients without ACS (P < .02 and P < .005, resp.). The present study reveals for the first time an association between increased Irs1 mRNA levels in MLs of patients with ACS which is not related to DM.
eng
Insulin receptor substrate-1 expression is increased in circulating leukocytes of patients with acute coronary syndrome
journal article
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URL
https://repisalud.isciii.es/bitstreams/ca0b5896-e8e8-4b8b-b82f-4ecfda4f0a19/download
File
MD5
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application/pdf
InsulinReceptorSubstrate-1Expression_2011..pdf
URL
https://repisalud.isciii.es/bitstreams/71a1bd93-930c-49d2-a01f-7098e627b707/download
File
MD5
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text/plain
InsulinReceptorSubstrate-1Expression_2011..pdf.txt