2026-04-30T03:51:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76492024-11-29T15:07:07Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
González-Rincón, Julia
author
Gómez, Sagrario
author
Martinez, Nerea
author
Troulé, Kevin
author
Perales-Patón, Javier
author
Derdak, Sophia
author
Beltrán, Sergi
author
Fernández-Cuevas, Belén
author
Pérez-Sanz, Nuria
author
Nova-Gurumeta, Sara
author
Gut, Ivo
author
Al-Shahrour, Fatima
author
Piris, Miguel A
author
García-Marco, José A
author
Sánchez-Beato, Margarita
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda
funder
Asociación Española Contra el Cáncer
2019-05-22T09:30:19Z
2019-05-22T09:30:19Z
2019-01-30
Sci Rep. 2019;9(1):975.
10.1038/s41598-018-37389-7
2045-2322
2045-2322
Scientific reports
30700761
http://hdl.handle.net/20.500.12105/7649
Chronic lymphocytic leukaemia is the most prevalent leukaemia in Western countries. It is an incurable disease characterized by a highly variable clinical course. Chronic lymphocytic leukaemia is an ideal model for studying clonal heterogeneity and dynamics during cancer progression, response to therapy and/or relapse because the disease usually develops over several years. Here we report an analysis by deep sequencing of sequential samples taken at different times from the affected organs of two patients with 12- and 7-year disease courses, respectively. One of the patients followed a linear pattern of clonal evolution, acquiring and selecting new mutations in response to salvage therapy and/or allogeneic transplantation, while the other suffered loss of cellular tumoral clones during progression and histological transformation.
eng
ACUTE MYELOID-LEUKEMIA
GENOME
MUTATIONS
ASXL1
Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia
journal article
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