2026-04-30T03:50:59Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/76492024-11-29T15:07:07Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc González-Rincón, Julia author Gómez, Sagrario author Martinez, Nerea author Troulé, Kevin author Perales-Patón, Javier author Derdak, Sophia author Beltrán, Sergi author Fernández-Cuevas, Belén author Pérez-Sanz, Nuria author Nova-Gurumeta, Sara author Gut, Ivo author Al-Shahrour, Fatima author Piris, Miguel A author García-Marco, José A author Sánchez-Beato, Margarita author 2019-01-30 Chronic lymphocytic leukaemia is the most prevalent leukaemia in Western countries. It is an incurable disease characterized by a highly variable clinical course. Chronic lymphocytic leukaemia is an ideal model for studying clonal heterogeneity and dynamics during cancer progression, response to therapy and/or relapse because the disease usually develops over several years. Here we report an analysis by deep sequencing of sequential samples taken at different times from the affected organs of two patients with 12- and 7-year disease courses, respectively. One of the patients followed a linear pattern of clonal evolution, acquiring and selecting new mutations in response to salvage therapy and/or allogeneic transplantation, while the other suffered loss of cellular tumoral clones during progression and histological transformation. Sci Rep. 2019;9(1):975. 10.1038/s41598-018-37389-7 2045-2322 2045-2322 Scientific reports 30700761 http://hdl.handle.net/20.500.12105/7649 ACUTE MYELOID-LEUKEMIA GENOME MUTATIONS ASXL1 Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia