2026-06-14T03:28:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/76272025-04-03T18:33:48Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938col_20.500.12105_16969
Repisalud
author
Casado, Concepcion
author
Pernas, Maria
author
Sandonis-Martin, Virginia
author
Alvaro-Cifuentes, Tamara
author
Olivares, Isabel
author
Fuentes-Fernandez, Rosa
author
Martínez-Prats, Lorena
author
Grau, Eulalia
author
Ruiz, Lidia
author
Delgado, Rafael
author
Rodríguez, Carmen
author
Del Romero, Jorge
author
Lopez-Galindez, Luis Cecilio
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Instituto de Salud Carlos III
2019-05-21T09:02:15Z
2019-05-21T09:02:15Z
2013
PLoS One. 2013 Oct 30;8(10):e77663.
10.1371/journal.pone.0077663
1932-6203
1932-6203
PloS one
24204910
http://hdl.handle.net/20.500.12105/7627
Long term non-progressor patients (LTNPs) are characterized by the natural control of HIV-1 infection. This control is related to host genetic, immunological and virological factors. In this work, phylogenetic analysis of the proviral nucleotide sequences in env gene from a Spanish HIV-1 LTNPs cohort identified a cluster of 6 HIV-1 controllers infected with closely-related viruses. The patients of the cluster showed common clinical and epidemiological features: drug user practices, infection in the same city (Madrid, Spain) and at the same time (late 70's-early 80's). All cluster patients displayed distinct host alleles associated with HIV control. Analysis of the virus envelope nucleotide sequences showed ancestral characteristic, lack of evolution and presence of rare amino-acids. Biological characterization of recombinant viruses with the envelope proteins from the cluster viruses showed very low replicative capacity in TZMbl and U87-CD4/CCR5 cells. The lack of clinical progression in the viral cluster patients with distinct combinations of protective host genotypes, but infected by low replicating viruses, indicate the important role of the virus in the non-progressor phenotype in these patients.
eng
Identification of a cluster of HIV-1 controllers infected with low replicating viruses
research article
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URL
https://repisalud.isciii.es/bitstreams/1f811825-7db2-4f5c-90c7-d052dafe1d95/download
File
MD5
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application/pdf
IdentificationOfACluster_2013.pdf
URL
https://repisalud.isciii.es/bitstreams/89ad7343-cca7-4294-94ef-edc61dd362a4/download
File
MD5
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text/plain
IdentificationOfACluster_2013.pdf.txt