2026-07-21T15:16:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/75872025-06-13T08:22:02Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Magro-Lopez, Esmeralda
author
Palmer, Charlotte
author
Manso, Joana
author
Liste-Noya, Isabel
author
Zambrano, Alberto
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
2019-05-17T10:41:20Z
2019-05-17T10:41:20Z
2018
Stem Cell Res Ther. 2018 Jul 11;9(1):186
10.1186/s13287-018-0943-9
1757-6512
1757-6512
Stem cell research & therapy
29996941
http://hdl.handle.net/20.500.12105/7587
Organoids from human pluripotent stem cells are becoming suitable models for studies of organ development, drug screening, regenerative medicine, and disease modeling. Three-dimensional minilungs in Matrigel culture have recently been generated from human embryonic stem cells. These particular organoids, named lung bud organoids, showed branching airway and early alveolar structures resembling those present in lungs from the second trimester of human gestation. We show here that the treatment of such organoids with a lung and airway epithelial maturation cocktail containing dexamethasone drives lung bud organoids to the formation of paddle-racquet like structures. This strategy may help to increase the versatility of lung organoids and to generate structures more advanced than the original branching texture.
eng
Dexamethasone
Human embryonic stem cells
Lung bud organoid
Lung epithelial maturation medium
Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids
research article
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URL
https://repisalud.isciii.es/bitstreams/be89793b-4758-4c13-b8b0-e97a5031e0e5/download
File
MD5
2082ff354c133c089bfc92cd74939c10
1110785
application/pdf
EffectsOfLungAnd_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/caf76768-75fd-48b1-97cc-643cc4edd451/download
File
MD5
4e47ceaf2ffa0c4c6294c55a6c4c98f6
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text/plain
EffectsOfLungAnd_2018.pdf.txt