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oai:repisalud.isciii.es:20.500.12105/75872025-06-13T08:22:02Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Magro-Lopez, Esmeralda author Palmer, Charlotte author Manso, Joana author Liste-Noya, Isabel author Zambrano, Alberto author 2018 Organoids from human pluripotent stem cells are becoming suitable models for studies of organ development, drug screening, regenerative medicine, and disease modeling. Three-dimensional minilungs in Matrigel culture have recently been generated from human embryonic stem cells. These particular organoids, named lung bud organoids, showed branching airway and early alveolar structures resembling those present in lungs from the second trimester of human gestation. We show here that the treatment of such organoids with a lung and airway epithelial maturation cocktail containing dexamethasone drives lung bud organoids to the formation of paddle-racquet like structures. This strategy may help to increase the versatility of lung organoids and to generate structures more advanced than the original branching texture. Stem Cell Res Ther. 2018 Jul 11;9(1):186 10.1186/s13287-018-0943-9 1757-6512 1757-6512 Stem cell research & therapy 29996941 http://hdl.handle.net/20.500.12105/7587 Dexamethasone Human embryonic stem cells Lung bud organoid Lung epithelial maturation medium Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids