2026-08-29T19:46:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/75792024-09-27T08:25:31Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Menchero, Sergio
author
Rollan, Isabel
author
Lopez-Izquierdo, Antonio
author
Andreu, Maria Jose
author
Sainz de Aja, Julio
author
Kang, Minjung
author
Adan, Javier
author
Benedito, Rui
author
Rayon, Teresa
author
Hadjantonakis, Anna-Katerina
author
Manzanares, Miguel
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2019-05-17T09:16:01Z
2019-05-17T09:16:01Z
2019-04-08
Elife. 2019; 8:e42930
10.7554/eLife.42930
2050-084X
2050-084X
eLife
30958266
http://hdl.handle.net/20.500.12105/7579
The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types. However, we still have limited knowledge about the role of Notch in early preimplantation stages of mammalian development, or how it interacts with other signalling pathways active at these stages such as Hippo. By using genetic and pharmacological tools in vivo, together with image analysis of single embryos and pluripotent cell culture, we have found that Notch is active from the 4-cell stage. Transcriptomic analysis in single morula identified novel Notch targets, such as early naïve pluripotency markers or transcriptional repressors such as TLE4. Our results reveal a previously undescribed role for Notch in driving transitions during the gradual loss of potency that takes place in the early mouse embryo prior to the first lineage decisions.
eng
Cdx2
Chromosomes
Developmental biology
Gene expression
Morula
Mouse
Notch
Preimplantation development
Trophectoderm
Transitions in cell potency during early mouse development are driven by Notch
journal article
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URL
https://repisalud.isciii.es/bitstreams/0db23609-1117-4563-b39d-b05ae1de1061/download
File
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application/pdf
TransitionsInCellPotencyDuring_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/231e3d7b-fa02-4d89-9ef5-368e7dad6e2f/download
File
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text/plain
TransitionsInCellPotencyDuring_2019.pdf.txt