2026-06-14T03:32:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/75692025-06-18T07:03:32Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2052com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_19616col_20.500.12105_16972
Repisalud
author
Mendez-Barbero, Nerea
author
Esteban, Vanesa
author
Villahoz, Silvia
author
Escolano, Amelia
author
Urso, Katia
author
Alfranca, Arantzazu
author
Rodriguez, Cristina
author
Sanchez, Susana A
author
Osawa, Tsuyoshi
author
Andres, Vicente
author
Martinez-Gonzalez, Jose
author
Minami, Takashi
author
Redondo, Juan Miguel
author
Campanero, Miguel R
funder
Ministerio de Economía y Competitividad (España)
funder
Consejo Superior de Investigaciones Científicas (España)
funder
Fundación Genoma España
funder
Fundación ProCNIC
funder
Instituto de Salud Carlos III
2019-05-14T10:00:50Z
2019-05-14T10:00:50Z
2013-12
EMBO Mol Med. 2013; 5(12):1901-17
10.1002/emmm.201302842
1757-4684
17574676
EMBO molecular medicine
24127415
http://hdl.handle.net/20.500.12105/7569
Atherosclerosis is a complex inflammatory disease involving extensive vascular vessel remodelling and migration of vascular cells. As RCAN1 is implicated in cell migration, we investigated its contribution to atherosclerosis. We show RCAN1 induction in atherosclerotic human and mouse tissues. Rcan1 was expressed in lesional macrophages, endothelial cells and vascular smooth muscle cells and was induced by treatment of these cells with oxidized LDLs (oxLDLs). Rcan1 regulates CD36 expression and its genetic inactivation reduced atherosclerosis extension and severity in Apoe(-/-) mice. This effect was mechanistically linked to diminished oxLDL uptake, resistance to oxLDL-mediated inhibition of macrophage migration and increased lesional IL-10 and mannose receptor expression. Moreover, Apoe(-/-) Rcan1(-/-) macrophages expressed higher-than-Apoe(-/-) levels of anti-inflammatory markers. We previously showed that Rcan1 mediates aneurysm development and that its expression is not required in haematopoietic cells for this process. However, transplantation of Apoe(-/-) Rcan1(-/-) bone-marrow (BM) cells into Apoe(-/-) recipients confers atherosclerosis resistance. Our data define a major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden.
eng
RCAN1
Atherosclerosis
Hypercholesterolemia
Inflammation
Macrophage
A major role for RCAN1 in atherosclerosis progression
research article
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URL
https://repisalud.isciii.es/bitstreams/243b2833-c2aa-4c9e-b51b-6a6d6d2d4145/download
File
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application/pdf
MajorRoleForRCAN1_2013.pdf
URL
https://repisalud.isciii.es/bitstreams/85e74a8c-177d-4ecc-9ba6-62774fc1247f/download
File
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text/plain
MajorRoleForRCAN1_2013.pdf.txt