2026-06-14T06:44:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/75652025-05-30T08:32:17Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Wingrove, Emily
author
Liu, Zongzhi Z
author
Patel, Kiran D
author
Arnal-Estapé, Anna
author
Cai, Wesley L
author
Melnick, Mary-Ann
author
Politi, Katerina
author
Monteiro, Catia
author
Zhu, Lucia
author
Valiente, Manuel
author
Kluger, Harriet M
author
Chiang, Veronica L
author
Nguyen, Don X
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación La Caixa
funder
Fundación Ramón Areces
funder
Bristol-Myers Squibb
funder
Beatrice Kleinberg Neuwirth Fundation
funder
Yale Lung Cancer
funder
Yale SPORE in Skin Cancer
2019-05-10T08:47:07Z
2019-05-10T08:47:07Z
2019-04-23
Cell Rep. 2019 ;27(4):1277-1292.
10.1016/j.celrep.2019.03.085
2211-1247
22111247
Cell reports
31018140
http://hdl.handle.net/20.500.12105/7565
The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based approach, which leverages the transcriptome of xenografts and distinguishes tumor cell and stromal gene expression with improved sensitivity and accuracy. Our data reveal shifts in epithelial and neuronal-like lineage programs in malignant cells as they adapt to the brain TME and the reciprocal neuroinflammatory response of the stroma. We identify several transcriptional hallmarks of metastasis that are specific to particular regions of the brain, induced across multiple tumor types, and confirmed in syngeneic models and patient biopsies. These data may serve as a resource for exploring mechanisms of TME co-adaptation within, as well as across, different subtypes of brain metastasis.
eng
Brain metastasis
Lineage plasticity
Neuroinflammation
Transcriptomic analysis in vivo
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis
journal article
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Supplementary_TranscriptomicHallmarksofTumor_2019.zip
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TranscriptomicHallmarksofTumor_2019.pdf.txt