2026-05-11T16:10:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/75582024-09-27T08:35:22Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Ng, Lai Guan
author
Ostuni, Renato
author
Hidalgo, Andres
funder
Singapore Immunology Network
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Italian Telethon Foundation
funder
Italian Association for Cancer Research
2019-05-09T08:17:37Z
2019-05-09T08:17:37Z
2019-04
Nat Rev Immunol. 2019; 19(4):255-65
10.1038/s41577-019-0141-8
1474-1741
1474-1733
Nature reviews. Immunology
30816340
http://hdl.handle.net/20.500.12105/7558
Structured models of ontogenic, phenotypic and functional diversity have been instrumental for a renewed understanding of the biology of immune cells, such as macrophages and lymphoid cells. However, there are no established models that can be used to define the diversity of neutrophils, the most abundant myeloid cells. This lack of an established model is largely due to the uniquely short lives of neutrophils, a consequence of their inability to divide once terminally differentiated, which has been perceived as a roadblock to functional diversity. This perception is rapidly evolving as multiple phenotypic and functional variants of neutrophils have been found, both in homeostatic and disease conditions. In this Opinion article, we present an overview of neutrophil heterogeneity and discuss possible mechanisms of diversification, including genomic regulation. We suggest that neutrophil heterogeneity is an important feature of immune pathophysiology, such that co-option of the mechanisms of diversification by cancer or other disorders contributes to disease progression.
eng
Heterogeneity of neutrophils
journal article
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URL
https://repisalud.isciii.es/bitstreams/c95de655-bc3d-481c-9ad6-bfbd26516705/download
File
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HeterogeneityOfNeutrophils_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/066beb6c-fa50-463d-b695-1fc4b7dc1ada/download
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HeterogeneityOfNeutrophils_2019.pdf.txt