2026-06-14T05:05:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/75492024-09-27T07:55:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Penkov, Dmitry
author
Mateos San Martín, Daniel
author
Fernandez-Díaz, Luis C
author
Rossello, Catalina A
author
Torroja, Carlos
author
Sanchez-Cabo, Fatima
author
Warnatz, H J
author
Sultan, Marc
author
Yaspo, Marie L
author
Gabrieli, Arianna
author
Tkachuk, Vsevolod
author
Brendolan, Andrea
author
Blasi, Francesco
author
Torres, Miguel
funder
Italian Association for Cancer Research
funder
Ministero dell Università e della Ricerca (Italia)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación ProCNIC
2019-05-07T11:57:15Z
2019-05-07T11:57:15Z
2013-04-25
Cell Rep. 2013; 3(4):1321-33
10.1016/j.celrep.2013.03.029
2211-1247
22111247
Cell reports
23602564
http://hdl.handle.net/20.500.12105/7549
The interactions of Meis, Prep, and Pbx1 TALE homeoproteins with Hox proteins are essential for development and disease. Although Meis and Prep behave similarly in vitro, their in vivo activities remain largely unexplored. We show that Prep and Meis interact with largely independent sets of genomic sites and select different DNA-binding sequences, Prep associating mostly with promoters and housekeeping genes and Meis with promoter-remote regions and developmental genes. Hox target sequences associate strongly with Meis but not with Prep binding sites, while Pbx1 cooperates with both Prep and Meis. Accordingly, Meis1 shows strong genetic interaction with Pbx1 but not with Prep1. Meis1 and Prep1 nonetheless coregulate a subset of genes, predominantly through opposing effects. Notably, the TALE homeoprotein binding profile subdivides Hox clusters into two domains differentially regulated by Meis1 and Prep1. During evolution, Meis and Prep thus specialized their interactions but maintained significant regulatory coordination.
eng
Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins
journal article
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URL
https://repisalud.isciii.es/bitstreams/3dfa59f3-eef0-48a3-98ed-55c10cab9862/download
File
MD5
6889b237109ea2891fde854be9b903f4
2010814
application/pdf
AnalysisDNA-BindingProfile_2013.pdf
URL
https://repisalud.isciii.es/bitstreams/954f4ff1-161b-44f4-8e0f-e78395a5e659/download
File
MD5
853106898ae64a845a738de66347b6da
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text/plain
AnalysisDNA-BindingProfile_2013.pdf.txt