2026-06-14T03:31:21Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/75492024-09-27T07:55:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607

00925njm 22002777a 4500 dc Penkov, Dmitry author Mateos San Martín, Daniel author Fernandez-Díaz, Luis C author Rossello, Catalina A author Torroja, Carlos author Sanchez-Cabo, Fatima author Warnatz, H J author Sultan, Marc author Yaspo, Marie L author Gabrieli, Arianna author Tkachuk, Vsevolod author Brendolan, Andrea author Blasi, Francesco author Torres, Miguel author 2013-04-25 The interactions of Meis, Prep, and Pbx1 TALE homeoproteins with Hox proteins are essential for development and disease. Although Meis and Prep behave similarly in vitro, their in vivo activities remain largely unexplored. We show that Prep and Meis interact with largely independent sets of genomic sites and select different DNA-binding sequences, Prep associating mostly with promoters and housekeeping genes and Meis with promoter-remote regions and developmental genes. Hox target sequences associate strongly with Meis but not with Prep binding sites, while Pbx1 cooperates with both Prep and Meis. Accordingly, Meis1 shows strong genetic interaction with Pbx1 but not with Prep1. Meis1 and Prep1 nonetheless coregulate a subset of genes, predominantly through opposing effects. Notably, the TALE homeoprotein binding profile subdivides Hox clusters into two domains differentially regulated by Meis1 and Prep1. During evolution, Meis and Prep thus specialized their interactions but maintained significant regulatory coordination. Cell Rep. 2013; 3(4):1321-33 10.1016/j.celrep.2013.03.029 2211-1247 22111247 Cell reports 23602564 http://hdl.handle.net/20.500.12105/7549 Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins