2026-04-29T12:22:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/75352024-09-27T08:19:05Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Alonso-Gonzalez, Noelia
author
Hidalgo, Andres
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Comisión Europea
funder
Fundación ProCNIC
2019-04-29T12:53:33Z
2019-04-29T12:53:33Z
2014
Front Immunol. 2014; 5:211
10.3389/fimmu.2014.00211
1664-3224
Frontiers in immunology
24860573
http://hdl.handle.net/20.500.12105/7535
Clearance of apoptotic cells by macrophages occurs as a coordinated process to ensure tissue homeostasis. Macrophages play a dual role in this process; first, a rapid and efficient phagocytosis of the dying cells is needed to eliminate uncleared corpses that can promote inflammation. Second, after engulfment, macrophages exhibit an anti-inflammatory phenotype, to avoid unwanted immune reactions against cell components. Several nuclear receptors, including liver X receptor and proliferator-activated receptor, have been linked to these two important features of macrophages during apoptotic cell clearance. This review outlines the emerging implications of nuclear receptors in the response of macrophages to cell clearance. These include activation of genes implicated in metabolism, to process the additional cellular content provided by the engulfed cells, as well as inflammatory genes, to maintain apoptotic cell clearance as an "immunologically silent" process. Remarkably, genes encoding receptors for the so-called "eat-me" signals are also regulated by activated nuclear receptors after phagocytosis of apoptotic cells, thus enhancing the efficiency of macrophages to clear dead cells.
eng
Apoptotic cell clearance
Inflammation
Liver X receptors
Macrophages
Nuclear receptors
Nuclear Receptors and Clearance of Apoptotic Cells: Stimulating the Macrophage's Appetite
journal article
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NuclearReceptorsClearanceApoptotic_20014.pdf.txt