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oai:repisalud.isciii.es:20.500.12105/75292024-09-27T09:14:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Esser, Claudia author Bachmann, Anna author Kuhn, Daniela author Schuldt, Kathrin author Förster, Birgit author Thiel, Meike author May, Jürgen author Koch-Nolte, Friedrich author Yanez-Mo, Maria author Sanchez-Madrid, Francisco author Schinkel, Alfred H author Jalkanen, Sirpa author Craig, Alister G author Bruchhaus, Iris author Horstmann, Rolf D author 2014-05 The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P.  falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P.  falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties. Cell Microbiol. 2014; 16(5):701-8 10.1111/cmi.12270 1462-5822 14625814 Cellular microbiology 24444337 http://hdl.handle.net/20.500.12105/7529 Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes