2026-08-05T12:20:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/74802024-09-27T17:37:15Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Mahillo-Fernandez, Ignacio
author
Pedro-Cuesta, Jesus de
author
Bleda, Maria Jose
author
Cruz, Mabel
author
Mølbak, Kåre
author
Laursen, Henning
author
Falkenhorst, Gerhard
author
Martínez-Martín, Pablo
author
Siden, Ake
author
EUROSURGYCJD Research Group
funder
Unión Europea. Comisión Europea
funder
Instituto de Salud Carlos III
2019-04-23T11:20:02Z
2019-04-23T11:20:02Z
2008
Neuroepidemiology. 2008;31(4):229-40.
10.1159/000163097
1423-0208
1423-0208
Neuroepidemiology
18843192
http://hdl.handle.net/20.500.12105/7480
BACKGROUND: Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial. METHODS: From Danish and Swedish registries we selected 167 definite and probable sCJD cases (with onset between 1987 and 2003) and 3,059 controls (835 age-, sex-, and residence-matched, and 2,224 unmatched). Independent of case/control status, surgical histories were obtained from National Hospital Discharge Registries. Surgical procedures were categorized by body system group and lag time to onset of sCJD. Exposure frequencies were compared using logistic regression. RESULTS: A history of any major surgery, conducted >/=20 years before sCJD onset, was more common in cases than both matched (OR = 2.44, 95% CI = 1.46-4.07) and unmatched controls (OR = 2.25, 95% CI = 1.48-3.44). This observation was corroborated by a linear increase in risk per surgical discharge (OR = 1.57, 95% CI = 1.13-2.18; OR = 1.50, 95% CI = 1.18-1.91). Surgery of various body systems, including peripheral vessels, digestive system and spleen, and female genital organs, was significantly associated with increased sCJD risk. CONCLUSIONS: A variety of major surgical procedures constitute a risk factor for sCJD following an incubation period of many years. A considerable number of sCJD cases may originate from health care-related accidental transmission.
eng
Surgery and risk of sporadic Creutzfeldt-Jakob disease in Denmark and Sweden: registry-based case-control studies
journal article
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SurgeryRiskSsporadicCreutzfeld_2008.pdf
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SurgeryRiskSsporadicCreutzfeld_2008.pdf.txt