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oai:repisalud.isciii.es:20.500.12105/74772024-11-29T23:26:54Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud author Jiang, Xia author Finucane, Hilary K author Schumacher, Fredrick R author Schmit, Stephanie L author Tyrer, Jonathan P author Han, Younghun author Michailidou, Kyriaki author Lesseur, Corina author Kuchenbaecker, Karoline B author Dennis, Joe author Conti, David V author Casey, Graham author Gaudet, Mia M author Huyghe, Jeroen R author Albanes, Demetrius author Aldrich, Melinda C author Andrew, Angeline S author Andrulis, Irene L author Anton-Culver, Hoda author Antoniou, Antonis C author Antonenkova, Natalia N author Arnold, Susanne M author Aronson, Kristan J author Arun, Banu K author Bandera, Elisa V author Barkardottir, Rosa B author Barnes, Daniel R author Batra, Jyotsna author Beckmann, Matthias W author Benitez, Javier author Benlloch, Sara author Berchuck, Andrew author Berndt, Sonja I author Bickeböller, Heike author Bien, Stephanie A author Blomqvist, Carl author Boccia, Stefania author Bogdanova, Natalia V author Bojesen, Stig E author Bolla, Manjeet K author Brauch, Hiltrud author Brenner, Hermann author Brenton, James D author Brook, Mark N author Brunet, Joan author Brunnström, Hans author Buchanan, Daniel D author Burwinkel, Barbara author Butzow, Ralf author Cadoni, Gabriella author Caldés, Trinidad author Caligo, Maria A author Campbell, Ian author Campbell, Peter T author Cancel-Tassin, Géraldine author Cannon-Albright, Lisa author Campa, Daniele author Caporaso, Neil author Carvalho, André L author Chan, Andrew T author Chang-Claude, Jenny author Chanock, Stephen J author Chen, Chu author Christiani, David C author Claes, Kathleen B M author Claessens, Frank author Clements, Judith author Collée, J Margriet author Correa, Marcia Cruz author Couch, Fergus J author Cox, Angela author Cunningham, Julie M author Cybulski, Cezary author Czene, Kamila author Daly, Mary B author deFazio, Anna author Devilee, Peter author Diez, Orland author Gago-Dominguez, Manuela author Donovan, Jenny L author Dörk, Thilo author Duell, Eric J author Dunning, Alison M author Dwek, Miriam author Eccles, Diana M author Edlund, Christopher K author Edwards, Digna R Velez author Ellberg, Carolina author Evans, D Gareth author Fasching, Peter A author Ferris, Robert L author Liloglou, Triantafillos author Figueiredo, Jane C author Fletcher, Olivia author Fortner, Renée T author Fostira, Florentia author Franceschi, Silvia author Friedman, Eitan author Gallinger, Steven J author Ganz, Patricia A author Garber, Judy author García-Sáenz, José A author Gayther, Simon A author Giles, Graham G author Godwin, Andrew K author Goldberg, Mark S author Goldgar, David E author Goode, Ellen L author Goodman, Marc T author Goodman, Gary author Grankvist, Kjell author Greene, Mark H author Gronberg, Henrik author Gronwald, Jacek author Guénel, Pascal author Håkansson, Niclas author Hall, Per author Hamann, Ute author Hamdy, Freddie C author Hamilton, Robert J author Hampe, Jochen author Haugen, Aage author Heitz, Florian author Herrero, Rolando author Hillemanns, Peter author Hoffmeister, Michael author Høgdall, Estrid author Hong, Yun-Chul author Hopper, John L author Houlston, Richard author Hulick, Peter J author Hunter, David J author Huntsman, David G author Idos, Gregory author Imyanitov, Evgeny N author Ingles, Sue Ann author Isaacs, Claudine author Jakubowska, Anna author James, Paul author Jenkins, Mark A author Johansson, Mattias author Johansson, Mikael author John, Esther M author Joshi, Amit D author Kaneva, Radka author Karlan, Beth Y author Kelemen, Linda E author Kühl, Tabea author Khaw, Kay-Tee author Khusnutdinova, Elza author Kibel, Adam S author Kiemeney, Lambertus A author Kim, Jeri author Kjaer, Susanne K author Knight, Julia A author Kogevinas, Manolis author Kote-Jarai, Zsofia author Koutros, Stella author Kristensen, Vessela N author Kupryjanczyk, Jolanta author Lacko, Martin author Lam, Stephan author Lambrechts, Diether author Landi, Maria Teresa author Lazarus, Philip author Le, Nhu D author Lee, Eunjung author Lejbkowicz, Flavio author Lenz, Heinz-Josef author Leslie, Goska author Lessel, Davor author Lester, Jenny author Levine, Douglas A author Li, Li author Li, Christopher I author Lindblom, Annika author Lindor, Noralane M author Liu, Geoffrey author Loupakis, Fotios author Lubiński, Jan author Maehle, Lovise author Maier, Christiane author Mannermaa, Arto author Marchand, Loic Le author Margolin, Sara author May, Taymaa author McGuffog, Lesley author Meindl, Alfons author Middha, Pooja author Miller, Austin author Milne, Roger L author MacInnis, Robert J author Modugno, Francesmary author Montagna, Marco author Moreno, Victor author Moysich, Kirsten B author Mucci, Lorelei author Muir, Kenneth author Mulligan, Anna Marie author Nathanson, Katherine L author Neal, David E author Ness, Andrew R author Neuhausen, Susan L author Nevanlinna, Heli author Newcomb, Polly A author Newcomb, Lisa F author Nielsen, Finn Cilius author Nikitina-Zake, Liene author Nordestgaard, Børge G author Nussbaum, Robert L author Offit, Kenneth author Olah, Edith author Olama, Ali Amin Al author Olopade, Olufunmilayo I author Olshan, Andrew F author Olsson, Håkan author Osorio, Ana author Pandha, Hardev author Park, Jong Y author Pashayan, Nora author Parsons, Michael T author Pejovic, Tanja author Penney, Kathryn L author Peters, Wilbert H M author Phelan, Catherine M author Phipps, Amanda I author Plaseska-Karanfilska, Dijana author Pring, Miranda author Prokofyeva, Darya author Radice, Paolo author Stefansson, Kari author Ramus, Susan J author Raskin, Leon author Rennert, Gad author Rennert, Hedy S author van Rensburg, Elizabeth J author Riggan, Marjorie J author Risch, Harvey A author Risch, Angela author Roobol, Monique J author Rosenstein, Barry S author Rossing, Mary Anne author De Ruyck, Kim author Saloustros, Emmanouil author Sandler, Dale P author Sawyer, Elinor J author Schabath, Matthew B author Schleutker, Johanna author Schmidt, Marjanka K author Setiawan, V Wendy author Shen, Hongbing author Siegel, Erin M author Sieh, Weiva author Singer, Christian F author Slattery, Martha L author Sorensen, Karina Dalsgaard author Southey, Melissa C author Spurdle, Amanda B author Stanford, Janet L author Stevens, Victoria L author Stintzing, Sebastian author Stone, Jennifer author Sundfeldt, Karin author Sutphen, Rebecca author Swerdlow, Anthony J author Tajara, Eloiza H author Tangen, Catherine M author Tardón, Adonina author Taylor, Jack A author Teare, M Dawn author Teixeira, Manuel R author Terry, Mary Beth author Terry, Kathryn L author Thibodeau, Stephen N author Thomassen, Mads author Bjørge, Line author Tischkowitz, Marc author Toland, Amanda E author Torres, Diana author Townsend, Paul A author Travis, Ruth C author Tung, Nadine author Tworoger, Shelley S author Ulrich, Cornelia M author Usmani, Nawaid author Vachon, Celine M author Van Nieuwenhuysen, Els author Vega, Ana author Aguado-Barrera, Miguel Elías author Wang, Qin author Webb, Penelope M author Weinberg, Clarice R author Weinstein, Stephanie author Weissler, Mark C author Weitzel, Jeffrey N author West, Catharine M L author White, Emily author Whittemore, Alice S author Wichmann, H-Erich author Wiklund, Fredrik author Winqvist, Robert author Wolk, Alicja author Woll, Penella author Woods, Michael author Wu, Anna H author Wu, Xifeng author Yannoukakos, Drakoulis author Zheng, Wei author Zienolddiny, Shanbeh author Ziogas, Argyrios author Zorn, Kristin K author Lane, Jacqueline M author Saxena, Richa author Thomas, Duncan author Hung, Rayjean J author Diergaarde, Brenda author McKay, James author Peters, Ulrike author Hsu, Li author García-Closas, Montserrat author Eeles, Rosalind A author Chenevix-Trench, Georgia author Brennan, Paul J author Haiman, Christopher A author Simard, Jacques author Easton, Douglas F author Gruber, Stephen B author Pharoah, Paul D P author Price, Alkes L author Pasaniuc, Bogdan author Amos, Christopher I author Kraft, Peter author Lindström, Sara funder Cancer Research UK (Reino Unido) funder NIHR - Comprehensive Biomedical Research Centre funder Guy ’ s & St. Thomas ’ NHS Foundation Trust funder NIHR - Oxford Biomedical Research Centre (Reino Unido) funder German Cancer Research Center funder Consejo Nacional de Ciencia y Tecnología (México) funder King College London funder National Health and Medical Research Council (Australia) funder Canadian Institutes of Health Research funder The BREast Oncology GAlician Network (BREOGAN funder Dietmar-Hopp Foundation funder Helmholtz Society and the German Cancer Research Center (DKFZ) funder Asociación Española Contra el Cáncer 2019-04-22T12:14:23Z 2019-04-22T12:14:23Z 2019-01-25 Nat Commun. 2019;10(1):431. 10.1038/s41467-018-08054-4 2041-1723 2041-1723 Nature communications 30683880 http://hdl.handle.net/20.500.12105/7477 Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. eng Shared heritability and functional enrichment across six solid cancers journal article 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 URL https://repisalud.isciii.es/bitstreams/6eef292d-041d-4bda-9ffb-284915fbdbf7/download File MD5 ac6d07ebc1716035de053e1c04e424a9 3765371 application/pdf SharedheritabilityandfunctionaL_2019.pdf URL https://repisalud.isciii.es/bitstreams/fe2b59fe-d8e2-4309-af4f-c9b68422d7b4/download File MD5 cde3b9b7d4cc0bdc28b74ddf5c97b59d 191155 text/plain SharedheritabilityandfunctionaL_2019.pdf.txt