2026-06-14T03:30:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/74752024-11-29T21:36:27Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Wasilewski, David
author
Priego, Neibla
author
Fustero-Torre, Coral
author
Valiente, Manuel
funder
Ministerio de Economía y Competitividad (España)
funder
Bristol-Myers Squibb
2019-04-22T11:03:22Z
2019-04-22T11:03:22Z
2017-12-11
Front Oncol. 2017;7:298.
10.3389/fonc.2017.00298
2234-943X
Frontiers in oncology
29312881
http://hdl.handle.net/20.500.12105/7475
Brain metastasis, the secondary growth of malignant cells within the central nervous system (CNS), exceeds the incidence of primary brain tumors (i.e., gliomas) by tenfold and are seemingly on the rise owing to the emergence of novel targeted therapies that are more effective in controlling extracranial disease relatively to intracranial lesions. Despite the fact that metastasis to the brain poses a unmet clinical problem, with afflicted patients carrying significant morbidity and a fatal prognosis, our knowledge as to how metastatic cells manage to adapt to the tissue environment of the CNS remains limited. Answering this question could pave the way for novel and more specific therapeutic modalities in brain metastasis by targeting the specific makeup of the brain metastatic niche. In regard to this, astrocytes have emerged as the major host cell type that cancer cells encounter and interact with during brain metastasis formation. Similarly to other CNS disorders, astrocytes become reactive and respond to the presence of cancer cells by changing their phenotype and significantly influencing the outcome of disseminated cancer cells within the CNS. Here, we summarize the current knowledge on the contribution of reactive astrocytes in brain metastasis by focusing on the signaling pathways and types of interactions that play a crucial part in the communication with cancer cells and how these could be translated into innovative therapies.
eng
Astrocyte signaling
Brain metastasis
Metastases therapy
Microenvironment heterogeneity
Reactive astrocytes
Reactive Astrocytes in Brain Metastasis
journal article
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URL
https://repisalud.isciii.es/bitstreams/4292638c-f3e8-44a8-a261-e3aead08d4ae/download
File
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reactiveastrocytesin_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/1b150dba-11fc-4059-9767-5cf7dba52080/download
File
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reactiveastrocytesin_2017.pdf.txt