2026-06-14T05:05:22Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/74652025-04-22T13:05:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Bartolini, Barbara author Gruber, Cesare EM author Koopmans, Marion author Avšič, Tatjana author Bino, Sylvia author Christova, Iva author Grunow, Roland author Hewson, Roger author Korukluoglu, Gulay author Lemos, Cinthia Menel author Mirazimi, Ali author Papa, Anna author Sánchez-Seco, María Paz author Sauer, Aisha V author Zeller, Hervè author Nisii, Carla author Capobianchi, Maria Rosaria author Ippolito, Giuseppe author Reusken, Chantal B author Di Caro, Antonino author 2019-01 BackgroundCrimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks.AimsTo review scientific literature and collect experts' opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans.MethodsWe conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVD-LabNet (Emerging Viral Diseases-Expert Laboratory Network).ResultsConsensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin.ConclusionNo effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses. Euro Surveill. 2019 Jan;24(5). 10.2807/1560-7917.ES.2019.24.5.1800093 1560-7917 Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 30722811 http://hdl.handle.net/20.500.12105/7465 CCHF CCHFV Crimean-Congo haemorrhagic fever virus European network Emerging diseases Laboratory preparedness Laboratory response Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks