2026-06-14T03:31:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/74382024-11-29T11:56:28Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19597col_20.500.12105_16984
Repisalud
author
Sánchez-Valle, Jon
author
Tejero, Héctor
author
Ibáñez, Kristina
author
Portero, José Luis
author
Krallinger, Martin
author
Al-Shahrour, Fatima
author
Tabarés-Seisdedos, Rafael
author
Baudot, Anaïs
author
Valencia, Alfonso
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Generalitat Valenciana (España)
2019-04-05T08:23:46Z
2019-04-05T08:23:46Z
2017-06-30
Sci Rep. 2017 ;7(1):4474
10.1038/s41598-017-04400-6
2045-2322
2045-2322
Scientific reports
28667284
http://hdl.handle.net/20.500.12105/7438
Epidemiological studies indicate that patients suffering from Alzheimer's disease have a lower risk of developing lung cancer, and suggest a higher risk of developing glioblastoma. Here we explore the molecular scenarios that might underlie direct and inverse co-morbidities between these diseases. Transcriptomic meta-analyses reveal significant numbers of genes with inverse patterns of expression in Alzheimer's disease and lung cancer, and with similar patterns of expression in Alzheimer's disease and glioblastoma. These observations support the existence of molecular substrates that could at least partially account for these direct and inverse co-morbidity relationships. A functional analysis of the sets of deregulated genes points to the immune system, up-regulated in both Alzheimer's disease and glioblastoma, as a potential link between these two diseases. Mitochondrial metabolism is regulated oppositely in Alzheimer's disease and lung cancer, indicating that it may be involved in the inverse co-morbidity between these diseases. Finally, oxidative phosphorylation is a good candidate to play a dual role by decreasing or increasing the risk of lung cancer and glioblastoma in Alzheimer's disease.
eng
A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer
journal article
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URL
https://repisalud.isciii.es/bitstreams/9ba7c101-490d-49db-ad08-e16ea02dc5b2/download
File
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Amolecularhypothesistoexplain_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/6d618795-6b4e-4ae5-a3d0-4b33fff1faff/download
File
MD5
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text/plain
Amolecularhypothesistoexplain_2017.pdf.txt