2026-06-14T05:05:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/74362024-11-29T18:13:16Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Veganzones, Silvia
author
de la Orden, Virginia
author
Requejo, Lucía
author
Mediero, Beatriz
author
González, María Luisa
author
Del Prado, Náyade
author
Rodríguez García, Carmen
author
Gutiérrez-González, Raquel
author
Pérez-Zamarrón, Alvaro
author
Martínez, Armando
author
Maestro, Marisa L
author
Zimman, Horacio Mario
author
González-Neira A, Anna
author
Vaquero, Jesús
author
Rodríguez-Boto, Gregorio
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía y Competitividad (España)
2019-04-04T09:45:17Z
2019-04-04T09:45:17Z
2017-08-01
Brain Behav. 2017;7(9):e00718.
10.1002/brb3.718
2162-3279
21623279
Brain and behavior
28948065
http://hdl.handle.net/20.500.12105/7436
BACKGROUND: This study evaluates the presence of R132H mutation in isocitrate dehydrogenase (IDH1) gene and the vascular endothelial growth factor (VEGF) +936 C/T polymorphism in brain tumors. The impact of these genetic alterations on overall survival (OS) and progression free survival (PFS) was evaluated. METHODS: A cohort of 80 patients surgically treated at Hospital Clínico San Carlos, Madrid, between March 2004 and November 2012, was analyzed. Tumors were distributed in 73 primary brain tumors (gliomas, meningiomas, hemangiopericytomas and hemangioblastomas) and seven secondary tumors evolved from a low grade glioma, thus providing a mixed sample. RESULTS: IDH1
R132H
gene mutation was found in 12 patients (15%) and appears more frequently in secondary tumors (5 (71.4%) whereas in 7 (9.7%) primary tumors (p < .001)). The mutation is related to WHO grade II in primary tumors and a supratentorial location in secondary tumors. The OS analysis for IDH1 showed a tendency towards a better prognosis of the tumors containing the mutation (p = .059).The IDH1
R132H
mutation confers a better PFS (p = .025) on primary tumors. The T allele of VEFG +936 C/T polymorphism was found in 16 patients (20%). No relation was found between this polymorphism and primary or secondary tumor, neither with OS or PFS. CONCLUSIONS: IDH1
R132H
gene mutation is exclusive in supratentorial tumors and more frequent in secondary ones, with a greater survival trend and better PFS in patients who carry it. The T allele of VEGF +936 C/T polymorphism is more common in primary tumors, although there is no statistical relation with survival.
eng
IDH1
VEGF
Brain tumors
Glioma
Survival
Genetic alterations of IDH1 and Vegf in brain tumors
journal article
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URL
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application/pdf
GeneticalterationsofIDH1andVegf_2017.pdf
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https://repisalud.isciii.es/bitstreams/dbeacd8d-5062-47fd-a611-be43fe4ce29b/download
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text/plain
GeneticalterationsofIDH1andVegf_2017.pdf.txt