2026-04-29T01:50:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73852025-06-09T09:10:45Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Lope Carvajal, Virginia
author
Perez-Gomez, Beatriz
author
Aragones, Nuria
author
Lopez-Abente, Gonzalo
author
Gustavsson, Per
author
Plato, Nils
author
Zock, Jan-Paul
author
Pollan-Santamaria, Marina
2019-03-26T15:34:06Z
2019-03-26T15:34:06Z
2008-11
Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3123-7.
1055-9965
http://hdl.handle.net/20.500.12105/7385
18990753
10.1158/1055-9965.EPI-08-0343
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
BACKGROUND: This study sought to identify occupations with high incidence of multiple myeloma and to investigate possible excess risk associated with occupational exposure to chemicals and sensitizing agents in Sweden. METHODS: A historical cohort of 2,992,166 workers was followed up (1971--1989) through record linkage with the National Cancer and Death Registries. For each job category, age and period standardized incidence ratios and age and period adjusted relative risks of multiple myeloma were calculated using Poisson models. Exposure to chemicals and to sensitizing agents was also assessed using two job-exposure matrices. Men and women were analyzed separately. RESULTS: During follow-up, 3,127 and 1,282 myelomas were diagnosed in men and women, respectively. In men, excess risk was detected among working proprietors, agricultural, horticultural and forestry enterprisers, bakers and pastry cooks, dental technicians, stone cutters/carvers, and prison/reformatory officials. In women, this excess was observed among attendants in psychiatric care, metal workers, bakers and pastry cooks, and paper/paperboard product workers. Workers, particularly bakers and pastry cooks, exposed to high molecular weight sensitizing agents registered an excess risk of over 40% across the sexes. Occasional, although intense, exposure to pesticides was also associated with risk of myeloma in our cohort. CONCLUSIONS: Our study supports a possible etiologic role for farming and use of pesticides in myeloma risk. The high incidence found in both female and male bakers and pastry cooks has not been described previously. Further research is required to assess the influence of high molecular weight sensitizing agents on risk of multiple myeloma.
eng
Occupation, exposure to chemicals, sensitizing agents, and risk of multiple myeloma in Sweden
preprint
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URL
https://repisalud.isciii.es/bitstreams/53e33769-d8b3-4fe2-b9ce-81801b8803f2/download
File
MD5
7ffd3cca79cf8801dc0413eb73d9fb73
273293
application/pdf
OccupationExposureChemicalsSensitizing.pdf
URL
https://repisalud.isciii.es/bitstreams/3742b142-d15e-4b27-890e-b331ddb74feb/download
File
MD5
d033e853c9ac184cb7dcdf6fcb89b57d
29890
text/plain
OccupationExposureChemicalsSensitizing.pdf.txt