2026-05-22T00:46:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73792025-04-30T07:37:11Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16967col_20.500.12105_16971
Repisalud
author
Martinez, Isidoro
author
Oliveros, Juan Carlos
author
Cuesta de la Plaza, Isabel
author
De la Barrera, Jorge
author
Ausina, Vicente
author
Casals, Cristina
author
de Lorenzo, Alba
author
García, Ernesto
author
García-Fojeda, Belén
author
Garmendia, Junkal
author
González-Nicolau, Mar
author
Lacoma, Alicia
author
Menéndez, Margarita
author
Moranta, David
author
Nieto, Amelia
author
Ortin, Juan
author
Pérez-González, Alicia
author
Prat-Vidal, Cristina
author
Ramos-Sevillano, Elisa
author
Regueiro, Verónica
author
Rodriguez-Frandsen, Ariel
author
Solís, Dolores
author
Yuste, Jose Enrique
author
Bengoechea, Jose Antonio
author
Melero, Jose Antonio
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
2019-03-26T15:00:07Z
2019-03-26T15:00:07Z
2017-03
Front Microbiol. 2017 Mar:276.
10.3389/fmicb.2017.00276
1664-302X
Frontiers in Microbiology
http://hdl.handle.net/20.500.13003/9927
28298903
L615662660
2-s2.0-85018302835
http://hdl.handle.net/20.500.12105/7379
394973500001
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
eng
Bacterial infections
Core of up-regulated genes
Host response
Respiratory pathogens
Viral infections
Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens
research article
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URL
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ApoptosisToll-likeRIG-I_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/028fb527-c0f7-4210-83f0-1e3735673627/download
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text/plain
ApoptosisToll-likeRIG-I_2017.pdf.txt