2026-05-20T22:56:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73552024-09-27T09:21:39Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Moreno-Gonzalo, Olga
author
Villarroya-Beltri, Carolina
author
Sanchez-Madrid, Francisco
funder
Ministerio de Ciencia e Innovación (España)
funder
Comunidad de Madrid (España)
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministerio de Educación y Ciencia (España)
2019-03-18T14:41:32Z
2019-03-18T14:41:32Z
2014
Front Immunol. 2014; 5:383
10.3389/fimmu.2014.00383
1664-3224
Frontiers in immunology
25157254
http://hdl.handle.net/20.500.12105/7355
Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection. Exosomes are small vesicles secreted to the extracellular environment through the release of intraluminal vesicles contained in multivesicular bodies (MVBs) upon the fusion of these MVBs with the plasma membrane. The composition of exosomes is not random, suggesting that the incorporation of cargo into them is a regulated process. However, the mechanisms that control the sorting of protein cargo into exosomes are currently elusive. Here, we review the post-translational modifications detected in exosomal proteins, and discuss their possible role in their specific sorting into exosomes.
eng
Exosomes
Multivesicular bodies
Post-translational modifications
Sorting
Ubiquitination
Post-translational modifications of exosomal proteins
journal article
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Post-translationalModificationsExosomalProteins_2014.pdf
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Post-translationalModificationsExosomalProteins_2014.pdf.txt