2026-07-23T17:50:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73542024-09-27T08:02:31Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Peralta, Marina
author
Gonzalez-Rosa, Juan Manuel
author
Marques, Ines Joao
author
Mercader, Nadia
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Ministerio de Economía y Competitividad (España)
2019-03-18T14:23:41Z
2019-03-18T14:23:41Z
2014-04-11
J Dev Biol. 2014; 2(2):101-116
10.3390/jdb2020101
2221-3759
Journal of developmental biology
24926432
http://hdl.handle.net/20.500.12105/7354
The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms' tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation.
eng
Development
Epicardium
Proepicardium
Regeneration
wt1a
wt1b
Zebrafish
The Epicardium in the Embryonic and Adult Zebrafish
journal article
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