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oai:repisalud.isciii.es:20.500.12105/73542024-09-27T08:02:31Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Peralta, Marina author Gonzalez-Rosa, Juan Manuel author Marques, Ines Joao author Mercader, Nadia author 2014-04-11 The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms' tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation. J Dev Biol. 2014; 2(2):101-116 10.3390/jdb2020101 2221-3759 Journal of developmental biology 24926432 http://hdl.handle.net/20.500.12105/7354 Development Epicardium Proepicardium Regeneration wt1a wt1b Zebrafish The Epicardium in the Embryonic and Adult Zebrafish