2026-04-29T12:22:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73532024-09-27T09:45:01Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Pernaute, Barbara
author
Spruce, Thomas
author
Smith, Kimberley M
author
Sánchez-Nieto, Juan Miguel
author
Manzanares, Miguel
author
Cobb, Bradley
author
Rodríguez, Tristan A
funder
Fundación ProCNIC
funder
Medical Research Council (Reino Unido)
funder
European Molecular Biology Organization
funder
Unión Europea. Comisión Europea
2019-03-18T14:01:40Z
2019-03-18T14:01:40Z
2014-09-01
Genes Dev. 2014; 28(17):1873-8
10.1101/gad.245621.114
1549-5477
0890-9369
Genes & development
25184675
http://hdl.handle.net/20.500.12105/7353
Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regulation as a key mechanism controlling apoptosis in the post-implantation epiblast. Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death.
eng
Bim
Dicer
Apoptosis
Epiblast
microRNAs
Pluripotency
MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM
journal article
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URL
https://repisalud.isciii.es/bitstreams/31d937c1-a1e0-443f-8fe3-b825aabc50c2/download
File
MD5
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application/pdf
MicroRNAsControlApoptoticThreshold_2014.pdf
URL
https://repisalud.isciii.es/bitstreams/84263fc0-4cf6-4ea3-b166-8c985d838ce0/download
File
MD5
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text/plain
MicroRNAsControlApoptoticThreshold_2014.pdf.txt