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oai:repisalud.isciii.es:20.500.12105/73532024-09-27T09:45:01Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Pernaute, Barbara author Spruce, Thomas author Smith, Kimberley M author Sánchez-Nieto, Juan Miguel author Manzanares, Miguel author Cobb, Bradley author Rodríguez, Tristan A author 2014-09-01 Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regulation as a key mechanism controlling apoptosis in the post-implantation epiblast. Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death. Genes Dev. 2014; 28(17):1873-8 0890-9369 http://hdl.handle.net/20.500.12105/7353 25184675 10.1101/gad.245621.114 1549-5477 Genes & development Bim Dicer Apoptosis Epiblast microRNAs Pluripotency MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM