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oai:repisalud.isciii.es:20.500.12105/73342024-09-27T20:19:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Parra, Mónica author Alcala, Adoración author Amoros, Cristina author Baeza, Anna author Galiana, Antonio author Tarrago Asensio, David author García-Quesada, Miguel Ángel author Sánchez-Hellín, Victoria author 2017-05-25 BACKGROUND: Primary Human herpesvirus-7 (HHV-7) infection usually occurs during childhood and causes several clinical manifestations: mainly exanthem subitum (roseola infantum), followed by a lifelong latent state with possible reactivation in case of immunodeficiency. Nevertheless, some considerably different approaches exist regarding the natural history of HHV-7 and the possible consequences of HHV-7 infection in immunocompetent adults. In particular, little is known about its pathogenic role in central nervous system (CNS) disease in nonimmunosuppressed adults. Specifically, in case of encephalitis, it is important to distinguish between infectious encephalitis and postinfectious encephalomyelitis for the management of patients CASE PRESENTATION: We describe here a case of encephalitis associated to human herpesvirus-7 with associated polymyeloradiculopathy in an immunocompetent patient which may contribute to the delineation of the approach to a patient profile with a similar clinical presentation and evolution to those presented in the literature. CONCLUSIONS: This case may alert clinicians to consider this specific etiology in the differential diagnosis of encephalopathy in patients with suspected infectious encephalitis who do not respond to acyclovir or in patients who develop acute polymyeloradiculopathy, considering that HHV-7 may be a pathological factor and that a timely diagnosis is crucial for the early administration of specific treatment. Virol J. 2017 May;14(1):97. 10.1186/s12985-017-0764-y 1743-422X Virology journal 28545483 http://hdl.handle.net/20.500.12105/7334 Clinical significance HHV-7 CNS infection Human herpesvirus-7 encephalitis Immunocompetent adults Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult