2026-06-14T03:28:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73142024-09-27T07:58:58Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Segales, Jessica
author
Perdiguero, Eusebio
author
Munoz-Canoves, Pura
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Pompeu Fabra University (España)
funder
Fundación La Marató TV3
2019-03-11T11:38:55Z
2019-03-11T11:38:55Z
2016
Front Cell Dev Biol. 2016; 4:91
10.3389/fcell.2016.00091
2296-634X
Frontiers in cell and developmental biology
27626031
http://hdl.handle.net/20.500.12105/7314
Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury in the adult constitutes an excellent paradigm to investigate the mechanisms whereby environmental cues control gene expression programs in muscle stem cells (satellite cells) by acting on transcriptional and epigenetic effectors. Here we will review the molecular mechanisms implicated in the transition of satellite cells throughout the distinct myogenic stages (i.e., activation from quiescence, proliferation, differentiation, and self-renewal). We will also discuss recent findings on the causes underlying satellite cell functional decline with aging. In particular, our review will focus on the epigenetic changes underlying fate decisions and on how the p38 MAPK signaling pathway integrates the environmental signals at the chromatin to build up satellite cell adaptive responses during the process of muscle regeneration, and how these responses are altered in aging. A better comprehension of the signaling pathways connecting external and intrinsic factors will illuminate the path for improving muscle regeneration in the aged.
eng
Aging
Epigenetics
Muscle stem cells
p38 MAPKs
Satellite cells
Tissue regeneration
Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway
journal article
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RegulationMuscleStemCell_2016.pdf
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https://repisalud.isciii.es/bitstreams/9b317249-e2b7-4be2-aaa6-5ffb9aef94bc/download
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RegulationMuscleStemCell_2016.pdf.txt