2026-07-21T14:27:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73102024-09-27T09:06:42Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Danne, Camille
author
Ryzhakov, Grigory
author
Martinez-Lopez, Maria
author
Ilott, Nicholas Edward
author
Franchini, Fanny
author
Cuskin, Fiona
author
Lowe, Elisabeth C
author
Bullers, Samuel J
author
Arthur, J Simon C
author
Powrie, Fiona
funder
Ministerio de Educación y Ciencia (España)
funder
Wellcome Trust
funder
Kennedy Trust
funder
Foundation Lous Jeantet
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2019-03-11T08:52:41Z
2019-03-11T08:52:41Z
2017-12-13
Cell Host Microbe. 2017; 22(6):733-745
10.1016/j.chom.2017.11.002
1934-6069
1931-3128
Cell host & microbe
29241040
http://hdl.handle.net/20.500.12105/7310
Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions between H. hepaticus and host immune cells that may promote mutualism, and the microbe-derived molecule(s) involved. Our results show that H. hepaticus triggers early IL-10 induction in intestinal macrophages and produces a large soluble polysaccharide that activates a specific MSK/CREB-dependent anti-inflammatory and repair gene signature via the receptor TLR2. These data identify a host-bacterial interaction that promotes mutualistic mechanisms at the intestinal interface. Further understanding of this pathway may provide novel prevention and treatment strategies for inflammatory bowel disease.
eng
CREB
Helicobacter hepaticus
MSK1/2
TLR2
Anti-inflammatory gene signature
Host-microbe interactions
Inflammatory bowel disease
Macrophage
Mutualism
Polysaccharide
A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages
journal article
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