2026-06-14T05:08:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73032024-09-27T09:51:19Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Torralba, Daniel
author
Baixauli, Francesc
author
Sanchez-Madrid, Francisco
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación ProCNIC
2019-03-08T11:40:54Z
2019-03-08T11:40:54Z
2016
Front Cell Dev Biol. 2016; 4:107
10.3389/fcell.2016.00107
2296-634X
Frontiers in cell and developmental biology
27734015
http://hdl.handle.net/20.500.12105/7303
Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, in addition to being maternally inherited, mitochondria can traverse cell boundaries and thus be horizontally transferred between cells. Although, the physiological relevance of this phenomenon is still under debate, mitochondria uptake rescues mitochondrial respiration defects in recipient cells and regulates signaling, proliferation or chemotherapy resistance in vitro and in vivo. In this review, we outline the pathophysiological consequences of horizontal mitochondrial transfer and offer a perspective on the cellular and molecular mechanisms mediating their intercellular transmission, including tunneling nanotubes, extracellular vesicles, cellular fusion, and GAP junctions. The physiological relevance of mitochondrial transfer and the potential therapeutic application of this exchange for treating mitochondrial-related diseases are discussed.
eng
DAMPs
Communication
Exosomes
Extracellular vesicles
Horizontal genetic transfer
Inflammation
Mitochondrial diseases
Tunneling nanotubes
Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer
journal article
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URL
https://repisalud.isciii.es/bitstreams/f9af2437-018e-4f03-b80a-7b114d5e63ca/download
File
MD5
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application/pdf
MitochondriaKnowNoBoundaries_2016.pdf
URL
https://repisalud.isciii.es/bitstreams/ed7e4835-abb7-4367-aed9-d6347d25f45f/download
File
MD5
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text/plain
MitochondriaKnowNoBoundaries_2016.pdf.txt