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oai:repisalud.isciii.es:20.500.12105/73032024-09-27T09:51:19Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Torralba, Daniel author Baixauli, Francesc author Sanchez-Madrid, Francisco author 2016 Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, in addition to being maternally inherited, mitochondria can traverse cell boundaries and thus be horizontally transferred between cells. Although, the physiological relevance of this phenomenon is still under debate, mitochondria uptake rescues mitochondrial respiration defects in recipient cells and regulates signaling, proliferation or chemotherapy resistance in vitro and in vivo. In this review, we outline the pathophysiological consequences of horizontal mitochondrial transfer and offer a perspective on the cellular and molecular mechanisms mediating their intercellular transmission, including tunneling nanotubes, extracellular vesicles, cellular fusion, and GAP junctions. The physiological relevance of mitochondrial transfer and the potential therapeutic application of this exchange for treating mitochondrial-related diseases are discussed. Front Cell Dev Biol. 2016; 4:107 10.3389/fcell.2016.00107 2296-634X Frontiers in cell and developmental biology 27734015 http://hdl.handle.net/20.500.12105/7303 DAMPs Communication Exosomes Extracellular vesicles Horizontal genetic transfer Inflammation Mitochondrial diseases Tunneling nanotubes Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer