2026-08-29T13:16:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/73022025-03-27T10:23:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lolo, Fidel Nicolas
author
Rius, Cristina
author
Casas-Tinto, Sergio
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación Jesús Serra
2019-03-07T13:40:30Z
2019-03-07T13:40:30Z
2017-12-15
Biol Open. 2017; 6(12):1897-1903
10.1242/bio.027300
2046-6390
Biology open
29162623
http://hdl.handle.net/20.500.12105/7302
Cellular interactions are critical during development, tissue fitness and epithelial tumor development. The expression levels of specific genes confer to tumoral cells a survival advantage versus the normal neighboring cells. As a consequence, cells surrounding tumors are eliminated and engulfed by macrophages. We propose a novel scenario in which circulating cells facing a tumor can reproduce these cellular interactions. In vitro cultured macrophages from murine bone marrow were used to investigate this hypothesis. M1 macrophages in tumoral medium upregulated markers of a suboptimal condition, such as Sparc and TyrRS, and undergo apoptosis. However, M2 macrophages display higher Myc expression levels and proliferate at the expense of M1. Resulting M1 apoptotic debris is engulfed by M2 in a Sparc- and TyrRS-dependent manner. These findings suggest that tumor-dependent macrophage elimination could deplete immune response against tumors. This possibility could be relevant for macrophage based anti-tumoral strategies.
eng
Alternatively-activated macrophages
Apoptosis
Classically-activated macrophages
Tumoral environment
Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages
journal article
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URL
https://repisalud.isciii.es/bitstreams/de9b7b46-369e-46ad-9639-fed84e77aac4/download
File
MD5
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application/pdf
EliminationOfClassically-Activated_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/5d863ed8-9b10-49bf-9495-6fbff27e5f42/download
File
MD5
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text/plain
EliminationOfClassically-Activated_2017.pdf.txt