2026-06-14T06:44:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/73022025-03-27T10:23:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Lolo, Fidel Nicolas author Rius, Cristina author Casas-Tinto, Sergio author 2017-12-15 Cellular interactions are critical during development, tissue fitness and epithelial tumor development. The expression levels of specific genes confer to tumoral cells a survival advantage versus the normal neighboring cells. As a consequence, cells surrounding tumors are eliminated and engulfed by macrophages. We propose a novel scenario in which circulating cells facing a tumor can reproduce these cellular interactions. In vitro cultured macrophages from murine bone marrow were used to investigate this hypothesis. M1 macrophages in tumoral medium upregulated markers of a suboptimal condition, such as Sparc and TyrRS, and undergo apoptosis. However, M2 macrophages display higher Myc expression levels and proliferate at the expense of M1. Resulting M1 apoptotic debris is engulfed by M2 in a Sparc- and TyrRS-dependent manner. These findings suggest that tumor-dependent macrophage elimination could deplete immune response against tumors. This possibility could be relevant for macrophage based anti-tumoral strategies. Biol Open. 2017; 6(12):1897-1903 10.1242/bio.027300 2046-6390 Biology open 29162623 http://hdl.handle.net/20.500.12105/7302 Alternatively-activated macrophages Apoptosis Classically-activated macrophages Tumoral environment Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages