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oai:repisalud.isciii.es:20.500.12105/73012025-03-24T14:30:17Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud author Brouckaert, Olivier author Rudolph, Anja author Laenen, Annouschka author Keeman, Renske author Bolla, Manjeet K author Wang, Qin author Soubry, Adelheid author Wildiers, Hans author Andrulis, Irene L author Arndt, Volker author Beckmann, Matthias W author Benitez, Javier author Blomqvist, Carl author Bojesen, Stig E author Brauch, Hiltrud author Brennan, Paul author Brenner, Hermann author Chenevix-Trench, Georgia author Choi, Ji-Yeob author Cornelissen, Sten author Couch, Fergus J author Cox, Angela author Cross, Simon S author Czene, Kamila author Eriksson, Mikael author Fasching, Peter A author Figueroa, Jonine author Flyger, Henrik author Giles, Graham G author González-Neira A, Anna author Guénel, Pascal author Hall, Per author Hollestelle, Antoinette author Hopper, John L author Ito, Hidemi author Jones, Michael author Kang, Daehee author Knight, Julia A author Kosma, Veli-Matti author Li, Jingmei author Lindblom, Annika author Lilyquist, Jenna author Lophatananon, Artitaya author Mannermaa, Arto author Manoukian, Siranoush author Margolin, Sara author Matsuo, Keitaro author Muir, Kenneth author Nevanlinna, Heli author Peterlongo, Paolo author Pylkäs, Katri author Saajrang, Suleeporn author Seynaeve, Caroline author Shen, Chen-Yang author Shu, Xiao-Ou author Southey, Melissa C author Swerdlow, Anthony author Teo, Soo-Hwang author Tollenaar, Rob A E M author Truong, Thérèse author Tseng, Chiu-Chen author van den Broek, Alexandra J author van Deurzen, Carolien H M author Winqvist, Robert author Wu, Anna H author Yip, Cheng Har author Yu, Jyh-Cherng author Zheng, Wei author Milne, Roger L author Pharoah, Paul D P author Easton, Douglas F author Schmidt, Marjanka K author Garcia-Closas, Montserrat author Chang-Claude, Jenny author Lambrechts, Diether author Neven, Patrick funder Unión Europea. Comisión Europea. 7 Programa Marco funder Cancer Research UK (Reino Unido) funder NIH - National Cancer Institute (NCI) (Estados Unidos) funder National Health and Medical Research Council (Australia) funder New South Wales Cancer Council (Reino Unido) funder Victorian Health Promotion Foundation funder Dutch Cancer Society (Holanda) funder Agence Nationale de la Recherche (Francia) funder French Agency for Food, Environmental and Occupational Health & Safety (Francia) funder Asociación Española Contra el Cáncer funder Instituto de Salud Carlos III funder Centro de Investigación Biomedica en Red - CIBER funder Federal Ministry of Education & Research (Alemania) funder Cancer Society of Finland funder Ministry of Education, Culture, Sports, Science, and Technology (Japón) funder Japan Agency for Medical Research and Development funder United States Army Medical Research and Development Command funder California Breast Cancer Research Program funder German Cancer Aid funder Ministry of Higher Education (Malasia) funder Biomedical Research Council (Singapore) funder National Institutes of Health (Estados Unidos) funder National Research Foundation of Korea 2019-03-07T12:45:17Z 2019-03-07T12:45:17Z 2017-11-07 Breast Cancer Res. 2017;19(1):119. 10.1186/s13058-017-0909-3 1465-542X 1465-542X Breast cancer research : BCR 29116004 http://hdl.handle.net/20.500.12105/7301 BACKGROUND: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. METHODS: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. RESULTS: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. CONCLUSIONS: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC. eng Age at breast cancer diagnosis Age at first full-time pregnancy Age at menarche Breast cancer subtype Parity Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study journal article 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 URL https://repisalud.isciii.es/bitstreams/b28b1506-ad60-4427-8b27-884a8d65cfce/download File MD5 3bcbe256c60ec112c0702dfc496e75bf 1351707 application/pdf Reproductiveprofilesandriskofbreast_2017.pdf URL https://repisalud.isciii.es/bitstreams/01c0db38-95de-4df0-a5f8-184e0cbbad87/download File MD5 e29aa4c8360274f34618376c75bd5f85 50137 application/vnd.openxmlformats-officedocument.wordprocessingml.document Reproductiveprofilesandriskofbreast_2017_MOESM1_ESM.docx URL https://repisalud.isciii.es/bitstreams/cad874f5-7a34-4ee5-9b44-7a43d292af71/download File MD5 e44d973dad42f5c7c6a19a09e97b47eb 65021 text/plain Reproductiveprofilesandriskofbreast_2017.pdf.txt URL https://repisalud.isciii.es/bitstreams/c71f6aa5-d45b-4c9b-b990-cde657ec44ec/download File MD5 56420c1047e1b9439ea38a13902cc18c 14820 text/plain Reproductiveprofilesandriskofbreast_2017_MOESM1_ESM.docx.txt