2026-06-14T05:06:25Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72972024-11-29T09:59:52Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19597col_20.500.12105_16977
Repisalud
author
Mancheño-Corvo, Pablo
author
Lopez-Santalla, Mercedes
author
Menta, Ramon
author
DelaRosa, Olga
author
Mulero, Francisca
author
Del Rio, Borja
author
Ramirez, Cristina
author
Büscher, Dirk
author
Bueren, Juan A
author
Lopez-Belmonte, Juan
author
Dalemans, Wilfried
author
Garin, Marina I
author
Lombardo, Eleuterio
funder
Ministerio de Ciencia y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea. 7 Programa Marco
2019-03-07T10:59:26Z
2019-03-07T10:59:26Z
2017-04-21
Front Immunol. 2017;8:462.
10.3389/fimmu.2017.00462
1664-3224
Frontiers in immunology
28484460
http://hdl.handle.net/20.500.12105/7297
Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues associated with the inflammatory site where functional MSC-induced immune cells with a regulatory phenotype were increased mediating the immunomodulatory effects of MSCs. These results suggest that homing of MSCs to the lymphatic system plays an important role in the mechanism of action of MSCs in vivo. Thus, we hypothesized that direct intralymphatic (IL) (also referred as intranodal) administration of MSCs could be an alternative and effective route of administration for MSC-based therapy. Here, we report the feasibility and efficacy of the IL administration of human expanded adipose mesenchymal stem cells (eASCs) in a mouse model of collagen-induced arthritis (CIA). IL administration of eASCs attenuated the severity and progression of arthritis, reduced bone destruction and increased the levels of regulatory T cells (CD25+Foxp3+CD4+ cells) and Tr1 cells (IL10+CD4+), in spleen and draining lymph nodes. Taken together, these results indicate that IL administration of eASCs is very effective in modulating established CIA and may represent an alternative treatment modality for cell therapy with eASCs.
eng
Adipose mesenchymal stem cells
Collagen-induced arthritis
Efficacy
Immunomodulation
Intralymphatic route
Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis
journal article
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