2026-06-14T05:05:38Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/72942024-09-27T09:42:25Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607

00925njm 22002777a 4500 dc Fernández-Barahona, Irene author Gutiérrez, Lucía author Veintemillas-Verdaguer, Sabino author Pellico, Juan author Morales, María del Puerto author Catala-Montoro, Mauro author del Pozo, Miguel Angel author Ruiz-Cabello, Jesús author Herranz, Fernando author 2019-02 Synthesizing iron oxide nanoparticles for positive contrast in magnetic resonance imaging is the most promising approach to bring this nanomaterial back to the clinical field. The success of this approach depends on several aspects: the longitudinal relaxivity values, the complexity of the synthetic protocol, and the reproducibility of the synthesis. Here, we show our latest results on this goal. We have studied the effect of Cu doping on the physicochemical, magnetic, and relaxometric properties of iron oxide nanoparticles designed to provide positive contrast in magnetic resonance imaging. We have used a one-step, 10 min synthesis to produce nanoparticles with excellent colloidal stability. We have synthesized three different Cu-doped iron oxide nanoparticles showing modest to very large longitudinal relaxivity values. Finally, we have demonstrated the in vivo use of these kinds of nanoparticles both in angiography and targeted molecular imaging. ACS Omega. 2019; 4(2):2719-2727 10.1021/acsomega.8b03004 2470-1343 ACS Omega http://hdl.handle.net/20.500.12105/7294 Cu-Doped Extremely Small Iron Oxide Nanoparticles with Large Longitudinal Relaxivity: One-Pot Synthesis and in Vivo Targeted Molecular Imaging